Growth curves for children with Laron syndrome on the basis of repeated measurements made throughout infancy, childhood, and puberty in 24 (10 boys, 14 girls) of 41 patients with this syndrome. Growth retardation was already noted at birth. Postnatal growth curves deviated sharply from the normal from infancy on. These growth curves constitute a model not only for primary, hereditary insulin-like growth factor-I (IGF-I) deficiency (Laron syndrome) but also for untreated secondary IGF-I deficiencies such as growth hormone gene deletion and idiopathic congenital isolated growth hormone deficiency.
Arch. Dis. Child. 1993 Jun;68(6):768-70Laron 1993 (Arch Dis Child) | PubMed 8333769 | Author Search