Growth Charts for Children With Down Syndrome in the United States

down_graphResults of the Down Syndrome Growing Up Study, which compiled 1520 measurements on 637 participants from 25 states (but mostly Pennsylvania) to create weight, height, head circumference, and body-mass index charts for children with Down syndrome through age 20 years. Comparisons to the old 1988 DS growth charts are illustrated. A supplement provides graphs and tables.

Zemel 2015 (Pediatrics) | PubMed 26504127 | Author Search

Growth Charts for Non-Growth Hormone Treated Prader-Willi Syndrome

Provides images of smoothed growth curves obtained from 120 non–growth hormone–treated white subjects with Prader-Willi Syndrome between 3 and 18 years of age from 4 states. Does not provide data that might allow one to implement the curves in an electronic format. Note published erratum citing minor formatting errors.

Butler 2014 (Pediatrics) | PubMed 25489013 | Author Search

Growth Charts for 22q11 Deletion Syndrome

Growth charts developed through retrospective chart review on 188 male and female patients with 22q11.2 deletion syndrome (DiGeorge syndrome and velo-cardio-facial syndrome confirmed by molecular cytogenetics). Some had cardiac anomalies, but it has been shown that presence of heart defects does not affect stature in this population. Although adult values for weight, BMI, and head circimference were similar to the normal population, adult height was lower in this syndrome than in the normal population.

Tarquinio 2012 (Am J Med Genet A) | PubMed 22887711 | Author Search

Growth Failure and Outcome in Rett Syndrome

rett_growth_chartsGrowth charts for classic and atypical Rett Syndrome were derived from 9,749 observations of 816 girls. Mean growth in classic RTT decreased below that for the normative population at 1 month for head circumference, 6 months for weight, and 17 months for length. Mean BMI was similar in those with RTT and the normative population. Pubertal increases in height and weight were absent in classic RTT. Classic RTT was associated with more growth failure than atypical RTT. Includes curves plotted along with CDC norms for comparison.

Tarquinio 2012 (Neurology) | PubMed 23035069 | Author Search

Clinical Tracking of Severely Obese Children: A New Growth Chart

Proposes a new type of growth chart that plots BMI againt the usual isobars plus an additional set that represent multiples of the 95th percentile for age/gender (x 1.1, x 1.2, x 1.3, etc.). Offers a way to indicate changes in body weight for the very obese that are perhaps more intuitive than the usual z-score method, and definitely more meaningful than percentiles. The screen shot in the article has been modified to label the isobars in a way that the software does not support.

Gulati 2012 (Pediatrics) | PubMed 23129082 | Author Search