Growth of Breast-Fed Infants Deviates From Current Reference Data: A Pooled Analysis of US, Canadian, and European Data Sets

Early recognition of the difference in growth patterns due to differences in diet among normal infants. This is the foundation of our understanding of the lower growth rates seen in health, breast-fed infants. These patterns are now incorporated into the recommended World Health Organization growth charts recommended for those under two years old in the United States. Dewey 1995 (Pediatrics)

The Natural History of Weight Percentile Changes in the First Year of Life

Another demonstration that growth in the first year of life is not as smooth as we’d like to think, and that “crossing percentile lines” does not mean what we have long been taught. Before you do a “failure to thrive workup” (whatever you think that is), check out this data to be sure you are interpreting “failed” growth appropriately. In this study from EMR data, 38% of infants fell by 2 “percentile lines” and would have been considered to be failing to thrive by that definition. But they were not.

Bennett 2014 (JAMA Pediatrics) | PubMed 24797161 | Author Search

Growth Curves for Laron Syndrome

Growth curves for children with Laron syndrome on the basis of repeated measurements made throughout infancy, childhood, and puberty in 24 (10 boys, 14 girls) of 41 patients with this syndrome. Growth retardation was already noted at birth. Postnatal growth curves deviated sharply from the normal from infancy on. These growth curves constitute a model not only for primary, hereditary insulin-like growth factor-I (IGF-I) deficiency (Laron syndrome) but also for untreated secondary IGF-I deficiencies such as growth hormone gene deletion and idiopathic congenital isolated growth hormone deficiency.

Arch. Dis. Child. 1993 Jun;68(6):768-70

Laron 1993 (Arch Dis Child) | PubMed 8333769 | Author Search