A Clinical Prediction Rule for Rebound Hyperbilirubinemia Following Inpatient Phototherapy

A report of a prediction rule for rebound hyperbilirubinemia (return of total serum bilirubin to phototherapy threshold within 72 hours of phototherapy termination) in newborns of at least 35 weeks’ gestation. Authors studied a group of ~7000 infants, 4.6% of whom had rebound hyperbilirubinemia. The formula is calculated as: 15 points if gestational age less than 38 weeks, minus 7 × (age in days at phototherapy initiation) minus 4 × (AAP phototherapy threshold − TSB at phototherapy termination) + 50. This score in turn can be applied to a curve (pictured) to predict rebound hyperbilirubinemia.

Chang 2016 (Pediatrics) | PubMed | Author Search